As mentioned in the note from SAP (2107965) there is a option to delete the *.exd files under users %appdata% folder...
I just wrote a quick batch script to take care of this since we allready pushed out the MS security updates and the EPM client doesn't want to refresh the reports anymore.
Feel free to use it however you want. And offcourse I take no responsability for it 
just open up notepad and paste below data into a new file that you save as for example BPC_MS_update_fix.bat
now you can send this to people needed this fix.
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@echo off
REM delete *.exd under %appdata% recursively
REM fix for MS security updates
del %appdata%\..\*.exd /S /Q
cls
echo.
echo Finished fixing MS security patches, please restart Excel!
echo.
pause
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Brgds
Mattias